Fri Sep 05 2025

31 articles - From Friday Aug 29 2025 to Friday Sep 05 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Inflamm Bowel Dis

Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease.

Overall, the goal of the group was to provide data-driven and practical guidance to improve the care of women with IBD around the globe based on the best available research.

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Meta-analysis

meta-analyses and systematic reviews

Pancreatology

Pylorus preservation after total pancreatectomy: a systematic review and meta-analysis.

PP during TP can reduce operative time but does not significantly impact postoperative outcomes, such as DGE, morbidity, or hospital stay. More prospective studies are needed to confirm these findings and to explore the potential benefits of PP in minimally invasive surgical approaches.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Apolipoprotein E -ε4-dependent associations between carotenoids and cognitive decline: Findings from the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) intervention for neurodegenerative delay (MIND) randomized controlled trial.

Higher plasma carotenoid concentrations were associated with slower cognitive decline in APOE-ε4 carriers, potentially mitigating genetic risk.

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Association of adiposity markers, serum 25-hydroxyvitamin D, and frailty in older adults: A prospective cohort study.

Older adults with both low adiposity markers and serum 25(OH)D had the highest frailty risk and the greatest increase in FI during follow-up. Guidelines for frailty prevention should consider both obesity markers and vitamin D status together in older adults.

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Cancer incidence and mortality risk: associations with diet quality scores in a predominantly low-income and Black cohort study.

Our study suggests that dietary indices are at most weakly related to cancer risk among the generally low-income SCCS participants. It highlights the need for more research on nutrition and cancer prevention in socioeconomically and racially diverse populations.

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Predicting total body water in infants aged 0.5-24 months and the implications for measuring breast milk intake: a secondary analysis of isotope dilution data.

The equation used in DTM calculations provides biased TBW estimates. This has implications for measuring breast milk intake and nonmilk water intake and our understanding of nutritional needs during the first 2 y of life.

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Inflamm Bowel Dis

Computer-Aided Detection Colonoscopy for Surveillance in IBD Patients: Insights from a Single-Center Experience.

In a real-world, single-center experience, the introduction of CADe did not improve neoplasms detection in patients with IBD and was associated with a nonsignificant decline in ADR. These findings call into question the utility of generic CADe systems in IBD surveillance and emphasize the need to foster IBD-specific CADe systems, as well as addressing challenges arising from physician-artificial intelligence interactions.

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Functional Profiling Demonstrates That a Sulfide-Reducing Diet Achieves Microenvironmental Targets in Ulcerative Colitis.

Here, we demonstrate that the objectives of the 4-SURE diet were fulfilled. This application of deep functional analysis to a dietary intervention study is novel and highlights an exemplar framework for including microbial and metabolomic biomarkers of pathogenic relevance in the analysis of therapeutic diet strategies. (Australian New Zealand Clinical Trials Registry, Number ACTRN12619000063112).

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RELA Haploinsufficiency Manifesting as an Atypical Phenotype of Crohn's Disease.

This study links RELA haploinsufficiency with CD-like features, Th1/Th17 polarization, and interferon-driven inflammation, emphasizing the importance of genetic evaluation in patients with atypical or refractory IBD.

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J Crohns Colitis

Combination therapy with biologics and/or small molecules in inflammatory bowel disease: a comprehensive review.

High treatment costs also pose a barrier to widespread adoption of ACT, though biosimilars may help offset these concerns. In summary, ACT may represent a potentially valuable therapeutic option in selected high-risk or treatment-resistant patients with inflammatory bowel disease; however, its true clinical benefit remains uncertain and requires confirmation through robust, well-powered randomised controlled trials.

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Faecal loss of vedolizumab is associated with UC severity, lower serum vedolizumab levels and rates of clinical response: Results from the FAVOUR study.

Active UC results in faecal loss of vedolizumab. This correlates with lower SVL and decreased response to treatment. Faecal loss of vedolizumab may be a marker of disease activity and/or result in lower rates of drug exposure at a tissue level, negatively impacting response.

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Modulating checkpoint molecules in inflammatory bowel diseases as a new therapeutic strategy: a narrative review.

Conversely, modulating checkpoint molecules offers a promising strategy to dampen the excessive immune response observed in immune-mediated inflammatory diseases (IMIDs) such as IBD. In this review, we provide a comprehensive overview of immune checkpoint molecules, explore the rationale for targeting them in IBD, and summarize current evidence from clinical trials investigating checkpoint modulation in IMIDs.

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Optimizing the switch from escalated intravenous to subcutaneous infliximab: a population pharmacokinetics-pharmacodynamics study.

Patients on Q6W and Q8W IV regimens may switch to standard SC infliximab without an increase in FC.

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Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis.

Submucosal hyper-echogenicity on IUS indicates fat deposition and predicts non-response in UC.

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Liver Transpl

Graft PD-L1 as a predictive marker for rejection in PD-1 inhibitor therapy for recurrent liver tumors post-transplant: A prospective pilot trial.

The median survival time after tumor recurrence was 24.6 months, exceeding the historically reported median survival time of 16.3 months. These exploratory findings suggest that, in selected liver transplant recipients, PD-1 inhibitors may be associated with reduced rejection risk and potential survival benefit, although further validation is needed.

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Post-liver transplantation outcomes in acute-on-chronic liver failure: Impact of alcohol as a precipitant and etiology of chronic liver disease.

While there were no differences in one year survival, AH-ACLF was associated with higher healthcare resource utilization compared to other ACLF precipitants. Liver transplant centers should ensure adequate resources are allocated for management of these patients.

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Potential missed opportunities to improve long-term liver allograft health.

By addressing both metabolic and immune pathways, these interventions represent a multifaceted approach to potentially optimize long-term liver allograft outcomes. Therefore, further research is warranted to determine their efficacy and safety in the liver transplant population.

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Pancreas

Nuclear Symmetric Dimethylarginine Staining is Indicative of Pancreatic Ductal Adenocarcinoma.

We demonstrate for the first time that nuclear SDMA staining is significantly enhanced in PDAC tissues and in the Islets of Langerhans of the pancreas, indicating novel tissue IHC markers for PDAC and the endocrine units of the pancreas.

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Pancreatology

A comparative analysis of gender and racial disparities in acute necrotizing pancreatitis outcomes: Insights from the national inpatient sample database.

This study reveals significant racial and gender disparities in NP outcomes, with males and Black patients experiencing distinct risks and care patterns. Future studies incorporating clinical and laboratory data across settings are warranted to validate these findings.

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Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

In our study, albumin replacement did not reduce the remission rate of SIRS or the rate of mortality at 60 days in patients with acute pancreatitis.

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Impact of coronavirus disease 2019 on the clinical outcomes of acute pancreatitis: a nationwide observational study in Japan.

Patients with concurrent COVID-19 infection, particularly those diagnosed during hospitalization, are at increased risk of severe AP and in-hospital mortality compared to those without COVID-19.

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Influence of prior bariatric surgery on pancreatic cancer stage at presentation and inpatient outcomes.

Patients with prior bariatric surgery often present with more advanced pancreatic head tumors which may reflect diagnostic challenges from altered anatomy, likely leading to higher metastatic rates. Despite this, they have lower inpatient mortality and better metabolic profiles. Early referral and specialized diagnostic techniques can improve staging and outcomes. As bariatric surgery is more often encountered, standardized clinical guidelines are needed.

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Outcomes of FOLFIRINOX versus gemcitabine plus nab-paclitaxel in patients with early recurrent pancreatic cancer after adjuvant S-1 treatment: A propensity score-matched analysis.

GnP was associated with improved OS compared to FOLFIRINOX for patients with early recurrence after adjuvant S-1.

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Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets.

This study prioritizes 26 proteins (tiers 1-3 targets) as potential therapeutic targets for CP, bridging proteomic insights to clinical translation.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

In pursuit of perfection: a small but important refinement of the isotopic measurement of human milk output.

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Inflamm Bowel Dis

Letter to the Editor Regarding "Real-World Comparison of Effectiveness, Treatment Persistence, and Safety of First-Line Advanced Therapies at 1 Year for Ulcerative Proctitis".

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Pancreatology

Defining oligo-recurrence criteria for locoregional intervention in pancreatic ductal adenocarcinoma: A multidisciplinary era perspective.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Clin Nutr

Reanalysis of the vitamin D and dementia association using the doubly-ranked nonlinear Mendelian randomization approach.

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Liver Transpl

The impact of frailty on liver transplant candidacy - A survey study on current clinical practices in the United States.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Establishing minimal reporting standards for unknown metabolites: an essential prerequisite for advancing nutritional metabolomics.

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Revised analyses do not provide compelling evidence of any benefit of vitamin D.

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